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Hand Sanitizer Gel Formulation PDF : Prevention of COVID-19 Coronavirus


Published on Sep 30, 2020

Hand Sanitizer Gel Formulation PDF : Prevention of COVID-19 Coronavirus

A hand sanitizing composition and a method of manufacture, wherein the composition includes a solvent from about 78% to about 96% by weight sufficient to operate as a carrier and solvent.

The composition includes tetrasodium EDTA and/or Sodium Citrate from about 0.01% to about 1% by weight to operate as a buffer, stabilizer and chelating agent. The composition includes a humectant selected from the group of humectants consisting of: Cetyl Alcohol, Ceteryl Alcohol, and Steryl Alchohol from about 1.5% to about 5.5% by weight to emulsify, thicken and lubricate. The composition includes an emollient from about 0.1% to about 3.2% by weight and an antioxidant vitamin from about 0.01% to about 1% by weight. The composition includes a soothing agent in a therapeutically significant amount and a conditioner.




Materials required (small volume production)

Hand Sanitizer

Method of Preparation

Ethanolic extract of Andrographis Paniculata, ginger, lemon was prepared by Maceration process. Other ingredients except triethanolamine were added in water and stirred well using a mechanical stirrer.

To this the extracts were added and stirred. Then triethanolamine and perfume was added and the volume was made up using alcohol.

10-Litre Preparations as Recommeded by WHO

These can be prepared in 10-litre glass or plastic bottles with screw-threaded stoppers.

1. The alcohol for the formula to be used is poured into the large bottle or tank up to the graduated mark.

2. Hydrogen peroxide is added using the measuring cylinder.

3. Glycerol is added using a measuring cylinder. As glycerol is very viscous and sticks to the wall of the measuring cylinder, it should be rinsed with some sterile distilled or cold boiled water and then emptied into the bottle/tank.

4. The bottle/tank is then topped up to the 10-litre mark with sterile distilled or cold boiled water.

5. The lid or the screw cap is placed on the tank/bottle as soon as possible after preparation, in order to prevent evaporation.

6. The solution is mixed by shaking gently where appropriate or by using a paddle.

7. Immediately divide up the solution into its final containers (e.g. 500 or 100 ml plastic bottles), and place the bottles in quarantine for 72 hours before use. This allows time for any spores present in the alcohol or the new/re-used bottles to be destroyed.

Uses of a Hand Sanitizer

These are antiseptic products used to avoid the transmission of skin infections/pathogens. Alcoholic hand sanitizer kills 99% of the bacteria on hands for seconds after application. Drying of the skin is less and leaves more moisture.

The above preparation can be used as a good hand sanitizer. Further studies are required to screen the antibacterial affect and compare with other available hand sanitizer

Handwashing and Hand Sanitizer Use

Germs are everywhere! They can get onto hands and items we touch during daily activities and make you sick. Cleaning hands at key times with soap and water or hand sanitizer is one of the most important steps you can take to avoid getting sick and spreading germs to those around you. There are important differences between washing hands with soap and water and cleaning them with hand sanitizer. For example, alcohol-based hand sanitizers don’t kill ALL types of germs, such as a stomach bug called norovirus, some parasites, and Clostridium difficile, which causes severe diarrhea. Hand sanitizers also may not remove harmful chemicals, such as pesticides and heavy metals like lead. Handwashing reduces the amounts of all types of germs, pesticides, and metals on hands. Knowing when to clean your hands and which method to use will give you the best chance of preventing sickness.

When should I use?

Soap and Water

• Before, during, and after preparing food

• Before eating food

• Before and after caring for someone who is sick

• Before and after treating a cut or wound

• After using the bathroom, changing diapers, or cleaning up a child who has used the bathroom

• After blowing your nose, coughing, or sneezing

• After touching an animal, animal food or treats, animal cages, or animal waste

• After touching garbage

• If your hands are visibly dirty or greasy

Alcohol-Based Hand Sanitizer

• Before and after visiting a friend or a loved one in a hospital or nursing home, unless the person is sick with Clostridium difficile (if so, use soap and water to wash hands).

• If soap and water are not available, use an alcohol-based hand sanitizer that contains at least 60% alcohol, and wash with soap and water as soon as you can.

* Do NOT use hand sanitizer if your hands are visibly dirty or greasy: for example, after gardening, playing outdoors, or after fishing or camping (unless a handwashing station is not available). Wash your hands with soap and water instead.

Use an alcohol-based hand sanitizer that contains at least 60% alcohol. Supervise young children when they use hand sanitizer to prevent swallowing alcohol, especially in schools and childcare facilities.

• Apply enough product on hands to cover all surfaces.

• Rub hands together, until hands feel dry. This should take around 20 seconds.

Note: Do not rinse or wipe off the hand sanitizer before it’s dry; it may not work as well against germs.


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