A biochip is a collection of miniaturized test sites (micro arrays) arranged on a solid substrate that permits many tests to be performed at the same time in order to get higher throughput and speed. Typically, a biochip’s surface area is not longer than a fingernail. Like a computer chip that can perform millions of mathematical operation in one second, a biochip can perform thousands of biological operations, such as decoding genes, in a few seconds.
A genetic biochip is designed to “freeze” into place the structures of many short strands of DNA (deoxyribonucleic acid), the basic chemical instruction that determines the characteristics of an organism. Effectively, it is used as a kind of “test tube” for real chemical samples.
A specifically designed microscope can determine where the sample hybridized with DNA strands in the biochip. Biochips helped to dramatically increase the speed of the identification of the estimated 80,000 genes in human DNA, in the world wide research collaboration known as the Human Genome Project. The microchip is described as a sort of “word search” function that can quickly sequence DNA.
In addition to genetic applications, the biochip is being used in toxicological, protein, and biochemical research. Biochips can also be used to rapidly detect chemical agents used in biological warfare so that defensive measures can be taken.
Motorola, Hitachi, IBM, Texas Instruments have entered into the biochip business
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